Regarded Solutions' June 18th column NOT free despite the author's ongoing promise that all his contributions would be free. Please explain.
CEO LETTER COVID-19 CLINICAL TRIAL
These are unprecedented and challenging times. My priority has been the safety and health of our employees and their families, and to continue the Company’s clinical trials as far as is feasibly possible.
At the same time, we have been working hard to see how we might help in the fight against COVID-19 more directly. On 28 April we announced our participation in a new UK national multi-centre randomised Phase 2 clinical trial initiative called ACCORD (ACcelerating COVID-19 Research & Development platform). BerGenBio’s bemcentinib was selected as the first candidate to be tested for its efficacy and safety in patients hospitalised with COVID-19.
Whilst our clinical focus for bemcentinib, a highly selective and potent inhibitor of AXL kinase, has been on the treatment of cancer, we have been aware of bemcentinib’santi-viral potential for some time, as demonstrated in preclinical models against viruses such as Ebola and Zika, with recent data expanding this to SARS-CoV-2. Bemcentinibselectively inhibits AXL kinase activity, blocking viral entry and enhancing the anti-viral type I interferon response, a key cellular defence mechanism against viral infection.
We are aware of the privilege and importance of having our drug selected for this national study and will be working closely with the Government Scientific Office, the National Institute for Health Research and designated CRO IQVIA to produce timely and high-quality results. If positive results are seen, bemcentinib will advance rapidly to Phase 3 testing and prepare for commercialisation to treat COVID-19 patients.
I’m particularly grateful and impressed by the vital pre-clinical research carried out by Professor Wendy Maury and her team at the University of Iowa, which discovered that the essential role of AXL is hi-jacked by viruses such as EBOLA and SARS-CoV-2 to enhance their infection rate and substantially improve their survival in host cells, and furthermore demonstrated the potential of bemcentinib as a treatment for viruses such as COVID-19. I also thank, and recognise the incredible effort made by, the BerGenBio team, alongside Tom Wilkinson’s team at the University of Southampton and IQVIA, to enable this important trial to get started so rapidly.
As for any company in the healthcare industry, we are seeking to improve the lives and treatment options for patients across the globe. This study will be important not only for COVID-19 patients, but should also serve to further validate bemcentinib as a promising treatment candidate for other aggressive diseases.
We look forward to keeping you all updated as we progress with the study, with the hope that bemcentinib can contribute to the global efforts to find an effective treatment for COVID-19.
The recent upgrade in the portfolio tracking service is impressive and graphically appealing. One aspect which can be improved is the "Today's % Gain" column. It correctly calculates the percentage gain or loss for the daily price change of each security position. However, it's calculation of the daily percentage change of the portfolio bears no resemblance with reality. What I think the developer did was mistakenly calculate an unweighted average of each individual security's percentage price change to the portfolio as a whole. The correct calculation (which was present in the previous version) compares the total value of the portfolio today with the previous closing value of the portfolio on the last trading day. If you could initiate a correction on this, it will be very helpful to those of us who like to compare our portfolio to index benchmarks. Thank you.
I like the new portfolio functionality very much. I'm puzzled by the negative reactions. I haven't used it very much obviously yet. But the one exception ... a lack of feature so bad where I almost think i must be making a user error:
Like with many brokerages... the portfolio page should have rows of tickers with average purchase price, average gain/loss percentage, and then sum gain and loss from all lots. Simply said, there should be one line per ticker, and then when you want to see the lot detail, you drill in.
With this design I will not put in my lots because I don't want to see them, unless I do.
Yes, I could build similar functionality in my own spreadsheet ... aggregating the many accounts I have. But this is convenient enough that I imagine using the SA portfolio function instead.
The new look is great. Especially the after hours details. Thanks.
One issue-- when looking at a sorted portfolio view, the page jumps up or down too often--- it may be when the ads refresh.
also, the top line with the drop down of portfolios and the exchanges' status disappears. It was better in the past when it remained in sight.
Preferred stock GNL.PB shows a chart when selected in Day Watch, but no price quote or any other related info on the Day Watch Page or the Detail page for the stock.
Just because I've been away for two weeks... shouldn't mean EVERY comment I post now has to be moderated, does it?
.... shouldn't mean EVERY comment I post now has to be moderated, does it?
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